Type VI secretion system sheath inter‐subunit interactions modulate its contraction
نویسندگان
چکیده
منابع مشابه
Type VI secretion system sheath inter‐subunit interactions modulate its contraction
Secretion systems are essential for bacteria to survive and manipulate their environment. The bacterial type VI secretion system (T6SS) generates the force needed for protein translocation by the contraction of a long polymer called sheath. The sheath is a six-start helical assembly of interconnected VipA/VipB subunits. The mechanism of T6SS sheath contraction is unknown. Here, we show that elo...
متن کاملVipA N-terminal linker and VipB-VipB interaction modulate the contraction of Type VI secretion system sheath
8 Secretion systems are essential for bacteria to survive and manipulate their environment. The 9 bacterial Type VI Secretion System (T6SS) generates the force needed for protein translocation 10 by the contraction of a long polymer called sheath, which is composed of interconnected 11 VipA/VipB subunits forming a six-start helix. The mechanism of T6SS sheath contraction and the 12 structure of...
متن کاملStructure of the Type VI Secretion System Contractile Sheath
Bacteria use rapid contraction of a long sheath of the type VI secretion system (T6SS) to deliver effectors into a target cell. Here, we present an atomic-resolution structure of a native contracted Vibrio cholerae sheath determined by cryo-electron microscopy. The sheath subunits, composed of tightly interacting proteins VipA and VipB, assemble into a six-start helix. The helix is stabilized b...
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متن کاملThe type VI secretion system sheath assembles at the end distal from the membrane anchor
The bacterial Type VI secretion system (T6SS) delivers proteins into target cells using fast contraction of a long sheath anchored to the cell envelope and wrapped around an inner Hcp tube associated with the secreted proteins. Mechanisms of sheath assembly and length regulation are unclear. Here we study these processes using spheroplasts formed from ampicillin-treated Vibrio cholerae. We show...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2017
ISSN: 1469-221X,1469-3178
DOI: 10.15252/embr.201744416